CONOLIDINE ALKALOID FOR CHRONIC PAIN NO FURTHER A MYSTERY

Most not long ago, it's been discovered that conolidine and the above derivatives act over the atypical chemokine receptor 3 (ACKR3. Expressed in identical parts as classical opioid receptors, it binds to some big range of endogenous opioids. Contrary to most opioid receptors, this receptor functions as a scavenger and doesn't activate a 2nd messen